How Long Can Vetsulin Be Out Of The Fridge? Rule Of Thumb!

Even your pet is at risk for diabetes mellitus. Although many people don’t know about this, it is one of the common diseases for them.

That’s why you should know about Vetsulin. This is considered a topical medicine for pets, and it also has some things to keep in mind during storage and use.

How long can Vetsulin be out of the fridge? I’ll tell you now!

What To Know About Vetsulin? 

how long can vetsulin be out of the fridge

What Is It?

When a dog has insufficient insulin levels or an aberrant reaction to insulin, it leads to an abundance of glucose, and diabetes will develop.

Diabetes in dogs is defined as a total or partial deficiency of insulin.

Pancreatic issues, other illnesses, or the presence of other hormones can all contribute to the development of diabetes mellitus in dogs.

This disease in dogs and cats is treated using veterinary insulin therapy, also known as Vetsulin. It is a type of long-acting insulin injected once or twice daily.

Vetsulin is a clear, colorless solution produced from recombinant human insulin.

This is a fast-acting insulin that starts working shortly after being injected. In dogs and cats with diabetes mellitus, Vetsulin efficiently regulates blood glucose levels.

How Does It Work?

Vetsulin is delivered by subcutaneous injection and is offered in U-40 Insulin Syringes and U-100 forms.

After mixing, the U-40 syringe has a shelf life of 28 days, whereas the U-100 formulation has a shelf life of 42 days.

How long can Vetsulin be left out of the fridge? The answer will be revealed in the next part.

Vetsulin can reduce blood sugar levels in cats and dogs because it is extremely similar to human insulin, which works best before meals.

Why Does Your Pet Need Vetsulin?

Your dog might first spend a few days in the hospital to handle urgent situations and start the insulin-regulating procedure.

Initial glucose measurements will be necessary to track development. A month or longer may be needed to obtain excellent insulin regulation.

A crucial element of managing a diabetic dog properly is consistent therapy.

Your dog requires regular insulin injections – particularly Vetsulin, regular meals, and stress-free living.

How Long Can Vetsulin Be Out Of The Fridge? 

does vetsulin need to be refrigerated

Short answer: It should still be fine if the Vetsulin storage temperature is not above 86°F for an extended time.

This insulin can be stored at room common condition for 28 to 42 days, depending on the type. Some even last for six weeks when out of the fridge.

If you have any reason to be concerned, throw away the bottle and purchase a new one.

Can I Keep The Vetsulin At Room Temperature?

Does Vetsulin need to be refrigerated? What happens if you don’t refrigerate Vetsulin?

As mentioned above, storing this animal-source insulin at room temperature may still be acceptable.

However, remember that high temperatures and direct sunlight can break the structure of the ingredients.

It can become dangerous when you inject your pet and even lead to some side effects.

So always check it before injecting, for example, when is the Vetsulin left out of the refrigerator overnight?

How Should I Store Vetsulin?

Hormone-like insulin will become ineffective if exposed to harsh light or extreme heat. Although it should be stored in the fridge, it shouldn’t be frozen.

It is safer to replace your dog’s insulin if you have any concerns about how it was stored than to take the chance of giving them ineffective insulin.

As long as it is used as recommended, insulin is safe. Keep it out of children’s reach, though.

The sealed vial that contains the insulin is marked with the insulin type and concentration. It is crucial to use the appropriate insulin needles for your dog’s needs.

The “units of insulin per mL” reading on insulin needles must be the same as the insulin concentration that you are using.

U-100 and U-40 are the two types of insulin and matching syringes that are most frequently used.

Contact your veterinarian for instructions on the kind of insulin you should use and the kind of syringe you should use.

How To Ensure Vetsulin Lasts As Long As Possible

The type of the animal, the accurate dosing, and the particular animal’s metabolism all affect how long Vetsulin stays in the body.

Duration of insulin taking effect typically lasts in dogs from 18 to 24 hours and 18 to 36 hours in cats.

The following suggestions will help Vetsulin last as long as possible:

  • Administering the correct dose of insulin based on the animal’s body weight and type. For example, a 50-pound dog will need more than a 20-pound one.
  • Avoid combining Vetsulin with other insulin products
  • Vetsulin should be injected into the animal’s fleshy body section, away from bones and joints.
  • It should also be stored appropriately (refrigerated, between 36 and 46 degrees Fahrenheit).


can vetsulin be left out overnight


What Are The Common Signs Of Inadequate or Excessive Vetsulin Dosage?

The veterinarian will probably perform blood glucose curves when a diabetic pet is first started on Vetsulin medication.

The results of this test will aid in determining the animal’s insulin needs.

Weakness, lethargy, allergic reaction, vomiting, and seizures are possible symptoms of a pet’s blood sugar level being too low due to incorrect dosing.

The animal may have increased thirst and urine, weight loss, and decreased appetite if the insulin becomes too high.

How Should I Draw Up The Vetsulin?

Insulin must be mixed before use since it is a suspension rather than a solution. While certain insulins should be shaken vigorously, others should only be softly rolled.

The main point is to blend it well while avoiding foam by vigorously mixing the ingredients.

Turn the bottle upside down after mixing the insulin to check if any white insulin molecules are still stuck to the bottom. If so, continue mixing.

Then, follow this guideline: 

  • After removing the needle’s cap, draw the plunger to the correct dosage.
  • Once the insulin has been mixed, carefully place the hand into the insulin bottle.
  • Fill the bottle with air by using the syringe. You will replace the liquid with this air.
  • Extra insulin should be drawn out and then injected back into the bottle.

What Affects The Duration Of Insulin Effect?

Many variables, including the animal’s species, the insulin dose, the kind of it, and the existence of a coexisting sickness, may impact the time veterinary insulin acts.

Compared to NPH insulin, regular insulin takes effect within a shorter period. Additionally, lente insulin’s duration of action is less than that of ultralente insulin.

The dose of veterinary insulin may also impact how long it lasts, with the duration of action increasing with the amount.

The existence of a concomitant disease may also have an impact on how long veterinary insulin acts.

The body may digest insulin more quickly when experiencing illness, shortening its duration of action.

Why Choose Vetsulin Over Human Insulin For Diabetic Dogs?

Vetsulin shares the same amino acid sequence as natural insulin in canines, but it’s different from the synthesized insulin in humans.

Because of the comparable structure, there may be more effective blood glucose control if you use Vetsulin. Besides, there will be less chance of producing anti-insulin antibodies.

Compared to the currently available insulin products for humans, Vetsulin promises better efficiency.


How long can Vetsulin be out of the fridge? It is probably safe for up to 42 days if the temperature is below 86°F, without direct exposure to sunlight and other heat sources.

However, no one can guarantee 100% quality when you inject your dog. Therefore, storing them in the refrigerator is best to ensure safety and avoid damage and danger to pets.


Photo of author
Hi I am Mitchell. Dog Growth is a blog about dog caring and training where I share my experiences to my community. Hope you enjoy it!

Leave a Comment